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Introduction to Doloxicam Injection
It is a pain-relieving medicine that helps in treating moderate to severe pain.
- This medicine relieves pain and swelling in conditions related to muscles and joints.
- It is generally injected when oral administration is not suitable.
Safety Advice for Doloxicam Injection
- Moderate risk
- High risk
- Safe
Caution is advised when consuming alcohol with this drug. Please consult your doctor.
It is unsafe to use during pregnancy as it may pose risk to the developing baby. Please consult your doctor.
It is considered to be safe to use during breastfeeding. The drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
It may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
It should be used cautiously in patients with severe kidney disease. Dose adjustment of the drug may be needed. Please consult your doctor.
The drug should be used with caution in patients with liver disease. Dose adjustment of drug may be needed. Please consult your doctor.
How Doloxicam Injection works
It is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that are responsible for inflammation (pain and swelling).
How To Use Doloxicam Injection
- Your doctor or nurse will give you this medicine. Kindly do not self administer.
- You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.
- Strictly follow the dose and duration suggested by a healthcare professional.
Special Precautions About Doloxicam Injection
- If side effects persist or get worse, you should let your doctor know.
- Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
- Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.
- Pregnant and breastfeeding mothers must consult with their doctors before using the medicine.
Benefits Of Doloxicam Injection
- Helps to relieve pain in conditions like osteoarthritis and rheumatoid arthritis.
Side Effects Of Doloxicam Injection
- Vomiting
- Stomach pain
- Nausea
- Indigestion
- Diarrhea
- Injection site reactions (pain, swelling, redness)
Similar Medicine Of Doloxicam Injection
What If I Missed A Dose Of Doloxicam Injection
- Don't skip any drug of the dose. If forgotten, take it once remembered.
- If the next dose time is near, skip the missed one.
- Avoid doubling to compensate. Follow this routine for safe and effective usage.
- For guidance on managing missed doses, consult your healthcare provider, ensuring proper adherence to the prescribed regimen.
Health And Lifestyle
Avoid overuse of alcohol. Maintain Balance diet and stay hydrated. If you are regularly exercising than incorporate light exercise to manage pain and Inflammation better.
Drug Interaction
- Anticoagulants (e.g., Warfarin)
- Antihypertensives (e.g., ACE inhibitors)
Drug Food Interaction
- Alcohol
- Grapefruit Juice
Disease Explanation
Pain- Pain signals the nervous system that something may be wrong, and can be sharp or dull, coming or going. It can be experienced in one area or all over. There are two types of pain: acute and chronic. Acute pain, sudden and often treated, can go away, while chronic pain can last for years and cause severe problems.
FAQ's on Doloxicam Injection
Can I use Doloxicam if I am pregnant?
No. Doloxicam should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
Can Doloxicam be used with lithium?
No. Doloxicam should not be used with lithium. Doloxicam leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
What is the difference between Doloxicam and nimesulide?
Both Doloxicam and nimesulide are pain killers. However, Doloxicam is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
Is Doloxicam a NSAID?
Yes. Doloxicam is a non-steroidal anti-inflammatory drug (NSAID).
Can I use Doloxicam if I have asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Can I use Doloxicam if I have peptic ulcer disease?
No. Doloxicam is contraindicated in cases of active peptic ulcer disease. Doloxicam is known to cause gastric ulceration and bleeding.
Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Doloxicam?
Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
How long does Doloxicam work?
Doloxicam is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
Can Doloxicam lead to difficulty in conception?
Yes. Doloxicam can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Can Doloxicam be used with methocarbamol?
Yes. Methocarbamol can be used with Doloxicam as no serious side effects are known. Inform your doctor before starting any of the medication.
Is Doloxicam a sulfa drug?
Doloxicam is a sulphur containing compound. Doloxicam can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
Can Doloxicam be used to treat menstrual cramp?
Doloxicam is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
Is Doloxicam a muscle relaxant?
No. Doloxicam is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
Can Doloxicam be used in the treatment of allergy?
No. Doloxicam is not a drug to treat allergy. It is a pain killer.
Is Doloxicam a blood thinner?
No. Doloxicam is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
Can Doloxicam lead to skin reactions?
Yes. Doloxicam is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
Can I use Doloxicam if I am a diabetic?
Doloxicam in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Doloxicam so taking piroxicam can lead to increased risk of renal failure by many folds.
Can Doloxicam be used along with Losartan?
No. Doloxicam should not be combined with Losartan. It is important to note that Doloxicam decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Doloxicam.
What are the serious side effects of Doloxicam?
GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.
What is the difference between Doloxicam and diclofenac?
Both Doloxicam and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Doloxicam.
Can Doloxicam be used in the treatment of chikungunya?
Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Doloxicam or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Doloxicam.
Can Doloxicam be used with diuretics?
No. Doloxicam should not be used with diuretics. Doloxicam reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Can Doloxicam be used along with paracetamol?
Yes. Paracetamol can be used with Doloxicam as no serious side effects are known. Inform your doctor before starting any of the medication.
Can you donate blood when on the medication with Doloxicam?
Yes. You can donate blood when on Doloxicam. Do inform your doctor before donating blood.
Are Doloxicam and aspirin same?
No. Doloxicam and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
What is the difference between Doloxicam and meloxicam?
Both Doloxicam and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Doloxicam.
Is Doloxicam affective in gout management?
Yes. Doloxicam can be given for the treatment of acute gout. Research studies have shown Doloxicam to be highly effective in the treatment of acute gout.
Can Doloxicam be used with Tizanidine?
Yes, Doloxicam can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
Can Doloxicam be used with Lisinopril?
No. Doloxicam should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Doloxicam.
What is the difference between Doloxicam and ketoprofen?
Both Doloxicam and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Doloxicam. Ketoprofen gel also showed excellent tolerability.
What increases the chances of getting a gastric ulcer when I am already taking Doloxicam?
The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
Can Doloxicam be used with calcium channel blocker?
Yes. Doloxicam can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
Can Doloxicam be used with warfarin?
No. Doloxicam should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
Can I use Doloxicam for a migraine?
Doloxicam is not approved for the treatment of migraine. Research studies have shown that Doloxicam is effective in significantly decreasing the pain associated with migraine without aura.
Can Doloxicam be used along with dexamethasone?
No. Doloxicam should not be used with dexamethasone. They both increase each others toxicity. There is an increased risk of GI ulceration.
Are there any alternatives of Doloxicam?
Yes. There are alternatives to Doloxicam. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
Is Doloxicam a narcotic?
No. Doloxicam is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
Is Doloxicam effective in back pain management?
Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Doloxicam as the cause of back pain can be different for different person.
What is the difference between Doloxicam and naproxen?
Both Doloxicam and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Doloxicam.
Can you get high by using Doloxicam?
No. Doloxicam is not known to cause high. It is a non-narcotic painkiller.
What is the difference between Doloxicam and tramadol?
Doloxicam is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
Can Doloxicam be used in hypertension?
No. Doloxicam is not a medication to control hypertension. It is important to note that Doloxicam decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Doloxicam.
Why is beta cyclodextrin added to Doloxicam?
Yes. Doloxicam can be combined with beta-cyclodextrin. Research has shown that combining Doloxicam with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
What are the contraindications for Doloxicam?
Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
Can I use Doloxicam if I have a deranged renal function?
No. Doloxicam should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
Written By
Rakshita Garg
M.Pharma
Content Updated on
Saturday, 27 July, 2024Prescription Required
Doloxicam Injection
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