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Introduction to Combigan Ophthalmic Solution 5ml
Combigan Ophthalmic Solution 5ml is a prescription medication designed to manage elevated intraocular pressure (IOP) in individuals with ocular hypertension or open-angle glaucoma. By effectively reducing IOP, Combigan helps prevent optic nerve damage and potential vision loss.
Safety Advice for Combigan Ophthalmic Solution 5ml
- High risk
- Moderate risk
- Safe
No interaction found/established
Information regarding the use of Combigan Ophthalmic Solution during pregnancy is not available. Please consult your doctor.
Information regarding the use of Combigan Ophthalmic Solution during breastfeeding is not available. Please consult your doctor.
Combigan Ophthalmic Solution may cause side effects which could affect your ability to drive.<BR>Combigan Ophthalmic Solution may cause blurred or abnormal vision. This effect may seem worse at night or in reduced lighting and this may affect the ability to drive.
No interaction found/established
No interaction found/established
How Combigan Ophthalmic Solution 5ml works
Combigan combines two active ingredients: brimonidine tartrate (0.2%) and timolol maleate (0.5%). Brimonidine Tartrate: An alpha-2 adrenergic receptor agonist that decreases aqueous humor production and enhances uveoscleral outflow, leading to reduced eye pressure. Timolol Maleate: A non-selective beta-adrenergic receptor blocker that lowers IOP by reducing the production of aqueous humor. The synergistic action of these components provides a more significant IOP reduction than either agent alone.
How To Use Combigan Ophthalmic Solution 5ml
- Wash your hands thoroughly.
- Tilt your head back and look upward.
- Gently pull down the lower eyelid to create a small pocket.
- Hold the dropper above the eye and squeeze out one drop into the pocket.
- Close your eye and apply gentle pressure to the inner corner for about 1 minute to prevent drainage.
- Avoid touching the dropper tip to any surface, including the eye, to maintain sterility.
Special Precautions About Combigan Ophthalmic Solution 5ml
- Medical History: Inform your doctor if you have conditions such as asthma, chronic obstructive pulmonary disease (COPD), heart diseases, diabetes, thyroid disorders, or depression.
- Allergic Reactions: Discontinue use and seek medical attention if you experience symptoms like eye redness, swelling, or itching.
- Operating Machinery: Combigan may cause temporary blurred vision or drowsiness. Avoid driving or operating heavy machinery until you are sure you can perform such activities safely.
- Surgical Procedures: Notify your surgeon or anesthetist that you are using Combigan if you are scheduled for surgery.
Benefits Of Combigan Ophthalmic Solution 5ml
- Effective IOP Reduction: Combigan Ophthalmic Solution combines two mechanisms to lower eye pressure more effectively than monotherapy.
- Convenient Dosing: Twice-daily administration simplifies treatment regimens.
- Proven Safety Profile: Clinical trials have demonstrated the efficacy and safety of Combigan in managing glaucoma and ocular hypertension.
Side Effects Of Combigan Ophthalmic Solution 5ml
- Common side effects may include: Eye irritation or redness, Burning or stinging sensation, Dry mouth, Headache, Drowsiness or fatigue.
- If side effects persist or worsen, consult your healthcare provider.
Similar Medicine Of Combigan Ophthalmic Solution 5ml
What If I Missed A Dose Of Combigan Ophthalmic Solution 5ml
- If you miss a dose of Combigan Ophthalmic Solution, apply it as soon as you remember.
- If it's near the time for the next dose, skip the missed dose and resume your regular schedule.
- Do not double the dose to catch up.
Health And Lifestyle
Diet: Maintain a balanced diet rich in fruits and vegetables to support overall eye health. Exercise: Engage in regular physical activity, as it may help reduce eye pressure. Hydration: Stay adequately hydrated throughout the day. Avoid Smoking: Smoking can exacerbate eye conditions; consider cessation programs if needed.
Drug Interaction
- Antihypertensives: May enhance blood pressure-lowering effects.
- Cardiac Glycosides: Potential additive effects on heart rate.
- CNS Depressants: Increased risk of drowsiness when combined with alcohol, sedatives, or anesthetics.
- Other Beta-Blockers: Avoid concurrent use of multiple beta-blocking agents.
Drug Food Interaction
- There are no significant food interactions with Combigan.
- However, it's advisable to limit caffeine and alcohol intake, as they can affect intraocular pressure.
Disease Explanation
Glaucoma: A group of eye conditions characterized by damage to the optic nerve, often due to elevated intraocular pressure. If untreated, it can lead to vision loss. Ocular Hypertension: Higher than normal eye pressure without detectable damage to the optic nerve or vision loss. It increases the risk of developing glaucoma.
Tips of Combigan Ophthalmic Solution 5ml
Consistent Use: Apply Combigan at the same times each day to maintain stable eye pressure.,Monitor Vision: Regularly check your vision and report any changes to your eye care specialist.,Scheduled Appointments: Keep regular appointments with your ophthalmologist to monitor eye health and treatment efficacy.
FactBox of Combigan Ophthalmic Solution 5ml
- Drug Class: Alpha-2 adrenergic receptor agonist & beta-blocker
- Composition: Brimonidine Tartrate (0.2%) + Timolol Maleate (0.5%)
- Usage: Treatment of ocular hypertension and open-angle glaucoma
- Dosage Form: Ophthalmic solution (eye drops)
Prescription Required - Storage: Store at room temperature (15-25°C), away from direct sunlight and moisture
- Shelf Life: Refer to packaging for expiry date
Storage of Combigan Ophthalmic Solution 5ml
- Temperature: Store Combigan eye drops at 15-25°C.
- Avoid Contamination: Keep the dropper tip clean and avoid contact with any surface.
- Keep Away from Children: Store in a safe place, out of reach of children.
- Do Not Freeze: Freezing may alter the composition and effectiveness of the medication.
Dosage of Combigan Ophthalmic Solution 5ml
Adults & Elderly: One drop of Combigan Ophthalmic Solution in the affected eye(s) twice daily, 12 hours apart.,Children: Not recommended for use in children under 2 years of age. Consult a doctor for pediatric usage.,Overdose: If an excessive amount is applied, rinse the eye with water and seek medical advice if necessary.
Synopsis of Combigan Ophthalmic Solution 5ml
Combigan 0.5/0.2% Eye Drops is a combination ophthalmic solution containing brimonidine tartrate and timolol maleate. It effectively reduces intraocular pressure in patients with open-angle glaucoma or ocular hypertension. With dual-action mechanisms, it minimizes aqueous humor production and enhances outflow, helping protect the optic nerve from damage. The medication is well-tolerated, with mild side effects such as eye irritation, dryness, or blurred vision. Proper administration and adherence to prescribed dosages ensure optimal results in eye pressure control and vision preservation.
FAQ's on Combigan Ophthalmic Solution 5ml
What is Combigan used for?
Combigan is used to lower intraocular pressure in individuals with glaucoma or ocular hypertension.
How long does it take for Combigan to work?
It starts reducing eye pressure within a few hours of application, with maximum effect seen after a few weeks.
Can I stop using Combigan if my eye pressure is normal?
No, stopping the medication abruptly can cause eye pressure to rise again. Always follow your doctor’s instructions.
What should I do if I accidentally use too many drops?
Rinse your eyes with water and seek medical attention if symptoms like dizziness or breathing difficulty occur.
Can I use Combigan with other eye drops?
Yes, but wait at least 5 minutes between different eye medications to prevent dilution.
Does Combigan cause drowsiness?
It may cause drowsiness or fatigue in some users. Avoid driving or operating machinery if you feel drowsy.
Can I wear contact lenses while using Combigan?
Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them.
Are there any dietary restrictions while using Combigan?
No strict dietary restrictions, but reducing caffeine and alcohol intake may help in managing eye pressure.
Can Combigan be used during pregnancy?
Consult your doctor before using this medication if you are pregnant or planning to conceive.
Is Combigan safe for children?
Combigan Ophthalmic Solution is not recommended for children under 2 years of age. Use in older children should be under medical supervision.
What happens if I miss a dose?
Apply the missed dose as soon as possible. If it''s close to the next dose, skip the missed dose and continue your schedule.
Can Combigan cause dry eyes?
Yes, some users may experience dry eyes. Using artificial tears can help relieve discomfort.
Can I use Combigan if I have asthma?
Inform your doctor, as timolol can cause breathing difficulties in asthma patients.
Does Combigan interact with other medications?
Yes, especially with beta-blockers, antihypertensives, and CNS depressants. Inform your doctor about all medications you take.
How should I store Combigan eye drops?
Store Combigan Ophthalmic Solution at 15-25°C, away from light and moisture. Keep the bottle tightly closed when not in use.
Can I use Combigan if I have diabetes?
Timolol may mask symptoms of low blood sugar. Diabetic patients should monitor their blood sugar levels closely.
Does Combigan affect blood pressure?
It may lower blood pressure, so patients with hypotension should use it cautiously.
Can Combigan cause blurry vision?
Yes, temporary blurred vision is a common side effect. Avoid activities that require clear vision immediately after use.
How long can I use a Combigan bottle after opening?
Typically, eye drops should be discarded after 4 weeks of opening unless stated otherwise by the manufacturer.
What should I do if my symptoms do not improve?
Consult your doctor for further evaluation and possible adjustments to your treatment plan.
Written By
Nish Kumar
B.Pharma + MBA
Content Updated on
Tuesday, 25 Feburary, 2025Prescription Required
Combigan Ophthalmic Solution 5ml
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