Many cases of pyrazinamide hepatotoxicity are severe and prolonged, and fatal instances have occurred. Pyrazinamide has not been linked to chronic hepatitis or vanishing bile duct syndrome. There is no cross reactivity of the hepatic injury with other currently available antituberculosis agents.

Rifampin, isoniazid, and pyrazinamide combination is used to treat tuberculosis (TB) infection. It may be taken alone or with one or more other medicines for TB. Rifampin belongs to the class of medicines called antibiotics and works to kill or prevent the growth of bacteria.

Nausea, vomiting, loss of appetite, or mild muscle/joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

You should take rifampicin on an empty stomach. This means that you should take your doses about an hour before a meal, or wait until two hours afterwards. This is because your body absorbs less rifampicin if taken at the same time as food, which means it is less effective.

The medications work best if they are taken all together one hour before, or two hours after, food and preferably with water. Ideally, the medications should be taken at the same time each day. For patients who have nausea, the medications can be taken with light food (eg, dry toast).

How it works: Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form which inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production which is necessary for the survival of the TB bacteria.

Pyrazinamide is used to treat tuberculosis (TB) in adults and children. Pyrazinamide must be used with other TB medicines. Tuberculosis can become resistant to treatment if pyrazinamide is used alone.

Physical Signs That TB Treatment Is Working Overall improvement in the way one feels. Weight gain. Increased appetite. Improvement in strength and stamina.

Pyzina kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyzina is not known

Fruits and vegetables like orange, mango, sweet pumpkin and carrots, guava, amla, tomato, nuts and seeds are an excellent source of Vitamin A, C and E. These foods must be included in the daily diet regime of a TB patient. TB patients tend to experience loss in appetite.

Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.

Headache, loss of appetite, upset stomach, or nausea/vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Pyzina is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

Your child should start to feel better and have fewer symptoms after taking the TB medicines for about 2 weeks. However, they must continue to take the medicine every day until the doctor says to stop treatment. This will be for 2 months for pyrazinamide and at least 6 months for the other medicines.

Following oral intake of Pyzina, it gets converted in the body to pyrazinoic acid (active chemical form of Pyzina). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

MUNICH — When first-line tuberculosis (TB) drugs are taken with food, there is a reduction in maximum plasma concentration and bioavailability of the drug than when taken on an empty stomach, according to the results of a new pharmacokinetic study.

Pyzina is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis