The bottom line The body may absorb cyanocobalamin better, while methylcobalamin has a higher retention rate. Both can prevent B12 deficiency, but methylcobalamin should be combined with adenosylcobalamin for best results.

Vitamin B12 was significantly associated with blood pressure when folic acid intake was high and vice versa. Considering that folic acid and vitamin B12 act together as cofactors in converting homocysteine into methionine,⁶ folic acid, and vitamin B12 may have synergic effects on blood pressure or endothelial function.

Dosage. For the best bioavailability and absorption, the recommended dose is 500 mcg three times daily or 1500 mcg daily of methylcobalamin or 5-adenosylcobalamin. Most generic vitamins contain cyanocobalamin, which may not be as effective or as beneficial.

Conclusions. MeCbl or its combined use with other agents has the potential analgesic effect in specific patients and animal models, for example, nonspecific low back pain; neck pain; diabetic neuropathic pain, subacute herpetic neuralgia, glossopharyngeal neuralgia, and trigeminal neuralgia.

Methycobal Tablet is a supplement of vitamin B12. It is used to treat low levels of vitamin B12 in your body. Vitamin B12 is essential in the formation of red blood cells and helps in the absorption of iron in the body. It also helps your body use fat and carbohydrates for energy and make new protein.

You may need to take vitamin B-12 separately from the above drugs and supplements — say, one in the morning and one at night — so you can get the full dose of vitamin B-12. Dont take vitamin B-12 supplements if you have sensitivities or allergies to vitamin B-12, cobalt, and any other ingredients.

The following doses have been studied in scientific research: ADULTS: BY MOUTH: The typical general supplemental dose of vitamin B12 is 1-25 mcg per day: The recommended dietary allowances (RDAs) of vitamin B12 are: 1.8 mcg; older children and adults, 2.4 mcg; pregnant women, 2.6 mcg; and breast-feeding women, 2.8 mcg.

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue. breathing problems. chest pain, tightness.

Despite the numerous processes in which vitamin B12 is involved, theres little evidence to suggest that it has any influence on weight gain or loss.

Adenosylcobalamin and methylcobalamin are considered to be the coenzyme forms, because they are whats used in enzymes in the body. The adenosylcobalamin form is selected when a biologically active form of vitamin B12 is desired and the formulations goal is to support the Krebs cycle and cellular energy production.

Vitamin B₁₂ at dosages found in foods or from supplements is well tolerated. GI effects from methylcobalamin may include anorexia, diarrhea, headache, nausea, and vomiting.