Glynase MF Tablet 10s

Glynase-MF is a combination of two medicines: Glipizide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glipizide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.

Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat diabetes mellitus type 2. It is used when dietary changes, exercise, and weight loss are not enough.

No, it is not safe to take Glynase-MF along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.

Yes, the use of Glynase-MF can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always carry some glucose tablets, honey or fruit juice with you.

The use of Glynase-MF should be avoided in patients with known allergy to any of the components or excipients of this medicine. It should also be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.

Glipizide helps with the release of insulin that occurs after a meal. These effects occur within 30 minutes of an oral dose of glipizide, even though it takes one to three hours for peak plasma concentrations to occur.

Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use.

Another comparative trial found that metformin provided better blood sugar control than glipizide. Those taking metformin in the study had better fasting plasma glucose levels than glipizide after 24, 36, and 52 weeks. Those taking metformin also had a lower HbA1c level than those taking glipizide after 52 weeks.

If you have either type 1 or type 2 diabetes, it means you have too much glucose (a type of sugar) in your blood. This is the same for both types. But the difference between them is how this happens. If you have type 1 diabetes, it means you have an autoimmune condition.

Glyburide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

CONCLUSIONS Glyburide and metformin are comparable oral treatments for GDM regarding glucose control and adverse effects. Their combination demonstrates a high efficacy rate with a significantly reduced need for insulin, with a possible advantage for metformin over glyburide as first-line therapy.

Adults—At first, 5 milligrams (mg) once a day taken at least 30 minutes before breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 40 mg per day.

The use of Glynase-MF is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to Vitamin B12 deficiency.

Metformin is still the safest and most effective type 2 diabetes medication, said Bolen. She is an assistant professor of medicine at Case Western Reserve Universitys Center for Health Care Research and Policy, in Cleveland.

Take the glipizide regular tablet 30 minutes before your first meal of the day. Take the glipizide extended-release tablet with your first meal of the day.

Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it.

Serious side effects of Glucotrol include hypoglycemia, jaundice, liver damage, fever, bleeding or bruising, skin changes, SIADH, and porphyria.

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Yes, the use of Glynase-MF can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glynase-MF and immediately consult your doctor.

Metformin is generally the preferred initial medication for treating type 2 diabetes, unless theres a specific reason not to use it. Metformin is effective, safe, and inexpensive. It may reduce the risk of cardiovascular events. Metformin also has beneficial effects when it comes to reducing A1C results.

Previous research indicates that the diabetes drugs sitagliptin and glipizide may not cause considerable kidney damage. New clinical trial results presented during the American Society of Nephrologys Annual Kidney Week compared the two drugs.

Yes, the use of Glynase-MF can cause Vitamin B12 deficiency on long-term use. It interferes with absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can feel a tingling sensation and numbness in the hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.