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Darzalex 400mg Injection

Name: Darzalex 400mg Injection
SKU: vial of 1 Injection
Price: 75000 INR
Availability: OutOfStock

by Janssen Pharmaceuticals

Salt CompositionDaratumumab (400mg)

₹75000

(vial of 1 Injection)

Stock : Out of Stock

Introduction to Darzalex 400mg Injection

Darzalex 400mg Injection is a prescription medication used for the treatment of multiple myeloma, a type of blood cancer affecting plasma cells. It contains Daratumumab (400mg), a monoclonal antibody that works by targeting and destroying cancerous plasma cells in the body. This medication is typically administered as an intravenous (IV) infusion under medical supervision in a hospital or clinical setting.

Darzalex is often used alone or in combination with other anti-cancer drugs such as bortezomib, lenalidomide, or dexamethasone. It helps slow down disease progression, improve overall survival, and enhance the quality of life in patients with multiple myeloma.

Before starting treatment with Darzalex 400mg Injection, it is important to discuss potential side effects, infusion reactions, and necessary precautions with your healthcare provider. Regular monitoring and follow-ups are required to ensure the treatment is effective and safe.

Safety Advice for Darzalex 400mg Injection

High risk
Moderate risk
Safe

There are no known direct interactions between Darzalex 400mg Injection and alcohol. However, alcohol consumption may weaken the immune system and worsen side effects such as dizziness or nausea.

Not recommended during pregnancy as Darzalex may harm the unborn baby. Women of childbearing age should use effective contraception during treatment and for 3 months after the last dose.

Darzalex may pass into breast milk, posing potential risks to the infant. Breastfeeding mothers should consult their doctor before use.

Some patients may experience dizziness, fatigue, or vision disturbances after receiving Darzalex. Avoid driving or operating machinery if these symptoms occur.

Darzalex Injection is not known to cause kidney damage, but patients with pre-existing kidney disease should use it with caution. Regular kidney function tests may be required.

Liver function should be monitored regularly, as Darzalex may cause elevated liver enzymes in some patients.

How Darzalex 400mg Injection works

Darzalex 400mg Injection contains Daratumumab, a monoclonal antibody that targets CD38, a protein found on the surface of myeloma cells. By binding to CD38, Daratumumab triggers immune system activation, leading to the destruction of cancerous plasma cells. Additionally, Darzalex reduces inflammation and suppresses tumor growth, improving treatment outcomes. It also helps enhance the body’s immune response against myeloma cells, slowing disease progression and improving survival rates.

How To Use Darzalex 400mg Injection

Darzalex 400mg Injection is administered intravenously (IV infusion) under the supervision of a healthcare professional.
The infusion process may take several hours, especially during the first dose.
Premedications such as corticosteroids, antihistamines, and acetaminophen may be given before infusion to reduce the risk of infusion-related reactions.
Your doctor will determine the exact dose and frequency based on your medical condition and treatment plan.

Special Precautions About Darzalex 400mg Injection

Monitor for infusion reactions such as fever, chills, breathing difficulties, or swelling.
Patients with chronic infections or weakened immune systems should use Darzalex 400mg Injection cautiously.
Inform your doctor if you have a history of hepatitis B, as Darzalex may reactivate the virus.
Complete blood count (CBC) tests should be conducted regularly to monitor blood cell levels.
Avoid live vaccines during and after treatment, as Darzalex can weaken the immune system.

Benefits Of Darzalex 400mg Injection

Darzalex 400mg Injection slows multiple myeloma progression, extending survival rates.
Improves immune system response to fight myeloma cells.
Effective in combination therapies, enhancing treatment outcomes.
Reduces symptoms such as bone pain and fatigue associated with multiple myeloma.
Well-tolerated in most patients when administered with premedications.

Side Effects Of Darzalex 400mg Injection

Infusion-related reactions (fever, chills, shortness of breath)
Fatigue and weakness
Nausea and vomiting
Low blood cell counts (anemia, neutropenia)
Upper respiratory infections
Diarrhea or constipation
Dizziness and headache

What If I Missed A Dose Of Darzalex 400mg Injection

Contact your doctor immediately if you miss a scheduled infusion.
Do not self-administer or adjust the dose without medical guidance.
Your healthcare provider will reschedule the missed dose based on your treatment plan.

Health And Lifestyle

Follow a healthy, protein-rich diet to support immune function and maintain strength. Stay hydrated to minimize side effects like nausea. Engage in light exercise to improve energy levels and reduce fatigue. Avoid crowded places to reduce infection risk. Monitor blood sugar levels, as Darzalex may cause fluctuations in diabetic patients.

Drug Interaction

Avoid combining Darzalex 400mg Injection with other immunosuppressants, as it may increase the risk of infections.
Live vaccines (e.g., MMR, varicella) should be avoided during treatment.
Certain medications like warfarin and immunomodulatory drugs may require dose adjustments.

Drug Food Interaction

No specific food interactions, but maintain a balanced diet to support overall health.
Avoid grapefruit juice, as it may interfere with medication metabolism.

Disease Explanation

Multiple myeloma is a type of blood cancer that affects plasma cells in the bone marrow. It leads to weakened bones, frequent infections, kidney problems, and anemia. Treatments like Darzalex help slow disease progression and improve quality of life.

FAQ's on Darzalex 400mg Injection

What is Darzalex 400mg Injection used for?

Darzalex 400mg Injection is used to treat multiple myeloma, a type of blood cancer that affects plasma cells. It helps slow disease progression and improves survival rates.

How does Darzalex 400mg work?

Darzalex contains Daratumumab, a monoclonal antibody that targets the CD38 protein on myeloma cells. It enhances the ability of the immune system to destroy these cancerous cells.

Is Darzalex Injection a chemotherapy drug?

No, Darzalex is not traditional chemotherapy. It is an immunotherapy that helps the immune system fight multiple myeloma more effectively.

How is Darzalex administered?

Darzalex is given intravenously (IV infusion) in a hospital under medical supervision. The first infusion may take several hours, while subsequent doses are typically shorter.

How long does a Darzalex infusion take?

The first infusion can take 6-8 hours. Subsequent infusions usually take 3-4 hours, depending on the response of your body.

What are the most common side effects of Darzalex?

Common side effects include infusion reactions (fever, chills, difficulty breathing), fatigue, nausea, diarrhea, respiratory infections, and low blood cell counts.

Can Darzalex cause hair loss?

No, Darzalex does not typically cause hair loss. It is not a chemotherapy drug, which is usually responsible for hair thinning or loss.

Can Darzalex be used as a standalone treatment?

Yes, in some cases. However, it is often used in combination with other medications like bortezomib, lenalidomide, or dexamethasone for better effectiveness.

How often is Darzalex given?

The dosing schedule varies. Initially, it is given once a week for the first cycle, then every two to four weeks depending on your treatment plan.

What precautions should I take before my Darzalex infusion?

Doctors usually prescribe pre-medications like corticosteroids, antihistamines, and acetaminophen to reduce the risk of infusion-related reactions.

Can I take Darzalex if I have an infection?

Patients with active infections should inform their doctor before receiving Darzalex, as it may weaken the immune system and worsen infections.

Can Darzalex be taken with other cancer treatments?

Yes, Darzalex is often combined with other multiple myeloma medications to improve effectiveness. Your doctor will determine the best combination for you.

What foods should I avoid while taking Darzalex?

There are no major food restrictions, but maintaining a healthy, balanced diet can support your immune system during treatment.

Can I get vaccinated while on Darzalex?

Avoid live vaccines (such as MMR or varicella) while on Darzalex, as it may weaken your immune response. Speak to your doctor before getting vaccinated.

Does Darzalex 400mg Injection increase the risk of infections?

Yes, because it affects the immune system. Patients may be at higher risk for respiratory infections like pneumonia or bronchitis.

Tips of Darzalex 400mg Injection

Take premedications as prescribed to prevent infusion-related reactions.
Keep track of blood test reports to monitor treatment response.
Report any unusual symptoms like bleeding, bruising, or infections to your doctor.
Avoid smoking and alcohol as they may worsen side effects.
Stay active with mild physical exercises to prevent fatigue.

FactBox of Darzalex 400mg Injection

Darzalex 400mg Injection is a monoclonal antibody therapy used for multiple myeloma.
It targets CD38 proteins on myeloma cells to enhance immune response.
Administered as an IV infusion under medical supervision.
Infusion-related reactions are the most common side effects.
Can be used alone or in combination with other anti-myeloma drugs.

Storage of Darzalex 400mg Injection

Store at 2°C to 8°C (refrigerated).
Do not freeze or shake the vial.
Keep away from direct sunlight and moisture.
Discard any unused portion as per hospital guidelines.

Dosage of Darzalex 400mg Injection

Dosage and infusion schedule for Darzalex 400mg Injection are determined by your doctor based on disease stage and response.
Usually given once a week for the first cycle, followed by every 2-4 weeks.

Synopsis of Darzalex 400mg Injection

Darzalex 400mg Injection (Daratumumab 400mg) is an approved therapy for multiple myeloma, working by targeting cancerous plasma cells. It is administered via IV infusion in a hospital setting and may be used alone or in combination with other therapies. While it offers significant benefits in disease control and survival, monitoring for infusion reactions and infections is essential.

Written By

Priyanka Sonkushre

Content Updated on

Saturday, 8 Feburary, 2025

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Darzalex 400mg Injection

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