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Introduction to Canmab 440mg Injection 1s
Canmab 440mg Injection 1s is a targeted therapy used primarily in the treatment of HER2-positive breast and stomach cancers. Manufactured by Biocon, it contains the active ingredient Trastuzumab, a monoclonal antibody designed to interfere with the HER2/neu receptor. Overexpression of this receptor is associated with aggressive tumor growth. By targeting HER2, Canmab helps inhibit the proliferation of cancer cells.
Safety Advice for Canmab 440mg Injection 1s
- High risk
- Moderate risk
- Safe
Canmab 440mg Injection may cause excessive drowsiness with alcohol.
Canmab 440mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Canmab 440mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
It is not known whether Canmab 440mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Canmab 440mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Canmab 440mg Injection may not be needed in these patients. Please consult your doctor.
There is limited information available on the use of Canmab 440mg Injection in patients with liver disease. Please consult your doctor.
How Canmab 440mg Injection 1s works
Trastuzumab, the active component of Canmab, binds specifically to the HER2 receptors on the surface of cancer cells. This binding blocks the receptors, preventing them from receiving growth signals. Additionally, Trastuzumab flags these cells for destruction by the body's immune system, enhancing the anti-tumor response. This dual action not only inhibits tumor growth but also promotes the elimination of cancer cells.
How To Use Canmab 440mg Injection 1s
- Administration: Canmab is administered intravenously by a qualified healthcare professional. The initial dose is typically infused over 90 minutes. If well-tolerated, subsequent doses may be given over 30 minutes.
- Dosage: The dosage and frequency of Canmab 440mg Injection depend on factors such as the type and stage of cancer, patient weight, and overall health. It's crucial to follow the treatment plan prescribed by your oncologist.
- Duration: For early breast cancer, treatment usually continues for one year or until disease recurrence, whichever occurs first. In metastatic cases, therapy may extend longer, based on response and tolerance.
Special Precautions About Canmab 440mg Injection 1s
- Cardiac Monitoring: Trastuzumab has been associated with cardiotoxicity. Regular heart function tests are recommended before and during treatment. Inform your doctor if you experience symptoms like shortness of breath, swelling, or irregular heartbeat.
- Pregnancy and Contraception: Canmab can cause harm to a developing fetus. Women of childbearing potential should use effective contraception during therapy and for at least seven months after the last dose. If you become pregnant during treatment, inform your doctor immediately.
- Breastfeeding: It's advised to avoid breastfeeding during treatment and for seven months following the final dose, as Trastuzumab may pass into breast milk and harm the infant.
Benefits Of Canmab 440mg Injection 1s
- Targeted Therapy: Canmab 440mg Injection specifically attacks HER2-positive cancer cells, sparing normal cells and reducing systemic side effects.
- Improved Survival Rates: Clinical studies have shown that Trastuzumab, in combination with other treatments, can improve overall survival and reduce the risk of cancer recurrence.
- Combination Potential: Canmab can be used alongside chemotherapy, hormonal therapy, or as a standalone treatment, offering flexibility in managing different cancer stages.
Side Effects Of Canmab 440mg Injection 1s
- Infusion Reactions: Fever, chills, and nausea during or shortly after the infusion.
- Cardiac Effects: Potential for heart-related issues, especially in patients with pre-existing heart conditions.
- Gastrointestinal Symptoms: Nausea, vomiting, diarrhea, or abdominal pain.
- Hematological Effects: Decreased blood cell counts, leading to anemia or increased infection risk.
- Respiratory Issues: Cough, shortness of breath, or other respiratory infections.
Similar Medicine Of Canmab 440mg Injection 1s
What If I Missed A Dose Of Canmab 440mg Injection 1s
- If you miss a scheduled dose of Canmab Injection, contact your healthcare provider immediately to reschedule.
- Do not attempt to self-administer or adjust the dosage without professional guidance.
Health And Lifestyle
Diet and Nutrition: Maintain a balanced diet to support overall health and recovery. Some patients may experience changes in appetite or taste; consulting a nutritionist can provide personalized advice. Physical Activity: Engage in regular, moderate exercise as tolerated to improve energy levels and overall well-being. Always consult your doctor before starting any new exercise regimen. Smoking and Alcohol: Avoid smoking and limit alcohol consumption, as they can interfere with treatment efficacy and increase side effect risks.
Drug Interaction
- Anthracyclines: Concurrent use may increase the risk of cardiac dysfunction.
- Taxanes: May enhance the risk of neutropenia (low white blood cell count).
Drug Food Interaction
- Currently, no specific food interactions have been identified with Canmab. However, maintaining a healthy diet supports overall treatment outcomes.
- Discuss any dietary supplements or significant dietary changes with your healthcare provider.
Disease Explanation
HER2-positive cancers overexpress the human epidermal growth factor receptor 2 (HER2), leading to rapid and uncontrolled cell growth. This subtype is more aggressive but responds well to therapies like Trastuzumab that specifically target the HER2 receptor.
Tips of Canmab 440mg Injection 1s
Adherence: Stick to your treatment schedule and attend all medical appointments.,Communication: Keep open lines of communication with your healthcare team. Report any new symptoms or concerns promptly.,Support Systems: Engage with support groups or counseling services to navigate the emotional challenges of cancer treatment.
FactBox of Canmab 440mg Injection 1s
- Generic Name: Trastuzumab
- Brand Name: Canmab
- Manufacturer: Biocon
- Drug Class: Monoclonal Antibody
- Indications: HER2-positive breast cancer, HER2-positive gastric cancer
- Route of Administration: Intravenous (IV)
- Dosage Form: Injection
- Common Side Effects: Fever, chills, nausea, cardiac effects
- Contraindications: Severe cardiac conditions, hypersensitivity to Trastuzumab
Storage of Canmab 440mg Injection 1s
- Temperature: Store Canmab 440mg Injection in a refrigerator (2°C – 8°C). Do not freeze.
- Protection: Keep the vial in its original packaging to protect it from light.
- Shelf Life: Use before the expiration date mentioned on the packaging.
- Handling: Once diluted, use immediately or store under refrigeration for up to 24 hours.
Dosage of Canmab 440mg Injection 1s
Early Breast Cancer: 8 mg/kg loading dose of Canmab Injection, followed by 6 mg/kg every 3 weeks.,Metastatic Breast Cancer: 4 mg/kg loading dose, then 2 mg/kg weekly.,Gastric Cancer: 8 mg/kg loading dose, then 6 mg/kg every 3 weeks.
FAQ's on Canmab 440mg Injection 1s
What is Canmab 440 mg Injection used for?
Canmab is used to treat HER2-positive breast and gastric cancers by targeting and blocking the HER2 protein, slowing cancer growth.
How does Canmab 440 mg Injection work?
It binds to HER2 receptors on cancer cells, preventing growth signals and marking them for destruction by the immune system.
How is Canmab 440 mg Injection administered?
It is given as an intravenous infusion under medical supervision.
What are the common side effects of Canmab?
Fever, chills, nausea, diarrhea, heart issues, and infusion-related reactions.
Can Canmab be taken during pregnancy?
No, it may harm the fetus. Effective contraception should be used during and up to 7 months after treatment.
Is it safe to breastfeed while on Canmab?
No, breastfeeding should be avoided as Trastuzumab may pass into breast milk.
What precautions should be taken before using Canmab?
Cardiac function should be monitored, and existing heart conditions must be discussed with the doctor.
How long does the treatment with Canmab last?
It depends on the type and stage of cancer; treatment typically lasts for one year in early breast cancer and longer for metastatic cases.
Does Canmab cause hair loss?
No, but it is often combined with chemotherapy, which may cause hair loss.
Can I drink alcohol while on Canmab treatment?
It is advisable to limit alcohol intake as it may exacerbate certain side effects.
What should I do if I miss a dose of Canmab?
Contact your doctor immediately to reschedule. Do not self-administer.
Are there any food restrictions while taking Canmab?
No specific food interactions, but a healthy diet is recommended for better recovery.
Can Canmab be used in children?
Canmab 440mg Injection is not commonly prescribed for children. Discuss with your doctor.
Does Canmab interact with other medications?
Yes, particularly with anthracyclines and taxanes. Inform your doctor about all medications.
How soon does Canmab start working?
It begins working immediately, but visible clinical improvements may take weeks to months.
What happens if I stop Canmab treatment early?
Stopping treatment early may lead to cancer recurrence or progression. Always follow your doctor’s advice.
Does Canmab affect fertility?
While Canmab Injection does not directly affect fertility, the overall cancer treatment may have an impact.
Is Canmab chemotherapy?
No, it is a targeted therapy, but it is often used alongside chemotherapy.
What should I do if I experience severe side effects?
Seek immediate medical attention and inform your healthcare provider.
Where can I buy Canmab 440 mg Injection?
It is available at hospitals, cancer treatment centers, and licensed pharmacies. You can also order from Dawaadost.
Is Canmab chemotherapy or targeted therapy?
Canmab is a targeted therapy, not traditional chemotherapy. It specifically targets cancer cells with HER2 overexpression.
Written By
Priyanka Sonkushre
Content Updated on
Saturday, 12 April, 2025Prescription Required
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